University

Antonello Enrico Spinelli is a researcher at the IRCCS San Raffaele Scientific Institute in Milan, where he coordinates preclinical activities in optical imaging and CT-based radiation therapy, as well as the research and development program in Cherenkov and radioluminescent imaging. His research focuses on advanced in vivo preclinical imaging modalities, particularly optical and CT imaging, and on innovative radiotherapy applications, such as Minibeam and FLASH radiotherapy.

He was among the pioneers in the fields of Cherenkov Luminescence Imaging (CLI) and Radioluminescence Imaging (RLI). Since 2008, he has been working on the preclinical development and clinical translation of CLI and RLI techniques, establishing methodologies for visualizing the optical photons generated by the decay of radiopharmaceuticals. His contributions have expanded the use of CLI and RLI from small-animal imaging to the evaluation of ex vivo tissues and even to the first clinical applications in humans, bridging the gap between nuclear medicine and optical imaging. Recently, he has extended Cherenkov imaging to the microscopic level for the study of in vitro 3D models.

Previously, he worked as a researcher in the field of small-animal PET and served as an adjunct professor of applied physics at the University of Bologna. Throughout his career, he has mentored and supervised students at various universities, including the University of Bologna, the University of Verona, and the Polytechnic University of Milan.

He is currently an Associate Professor of Medical Physics in the Department of Life Sciences, Health, and Health Professions at Link Campus University.

Curriculum Vitae